Immune Dysfunction
Activation of NK cells in male cancer survivors by fucoidan extracted from Cladosiphon okamuranus
Urinary Bladder Cancer
AKT signaling is involved in fucoidan-induced inhibition of growth and migration of human bladder cancer cells
Autoimmune Diseases
Amelioration of Experimental Autoimmune Encephalomyelitis in Lewis Rats Treated with Fucoidan
Gastric Cancer
An Exploratory Study on the Anti-inflammatory Effects of Fucoidan in Relation to Quality of Life in Advanced Cancer Patients
Leukemia
Anti tumor activity of fucoidan in acute promyelocytic leukemia and its synergy with arsenic trioxide and ATRA
Leukemia
Anti tumor activity of fucoidan in acute promyelocytic leukemia and its synergy with arsenic trioxide and ATRA in vitro and in vivo
General Anti-inflammatory & Antioxidant
Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review
Anti-inflammatory & Antioxidant
Anti-Inflammatory Mechanisms of Fucoidans to Treat Inflammatory Diseases: A Review (PMC8703547)
Prostate Cancer
Anti-tumor and anti-angiogenic effects of Fucoidan on prostate cancer: possible JAK-STAT3 pathway
Liver Cancer
Antiangiogenic drugs in combination with seaweed fucoidan: A mechanistic in vitro and in vivo study
Liver Cancer
Antiangiogenic drugs in combination with seaweed fucoidan: A mechanistic in vitro and in vivo study exploring the VEGF receptor and its downstream signaling molecules in hepatic cancer
Prostate Cancer
In Vitro Study
Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway
Prostate Cancer
Anticancer Effect of Fucoidan on DU-145 Prostate Cancer Cells through Inhibition of PI3K/Akt and MAPK Pathway Expression
Colon Cancer
Anticancer Effects of Different Seaweeds on Human Colon and Breast Cancers
Breast Cancer
Anticancer properties and mechanisms of fucoidan on mouse breast cancer in vitro and in vivo
Liver Cancer
Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3
Liver Cancer
Antimetastatic Effect of Fucoidan-Sargassum against Liver Cancer Cell Invadopodia Formation via Targeting Integrin αVβ3 and Mediating αVβ3/Src/E2F1 Signaling
Anti-inflammatory & Antioxidant
Antioxidant and anticancer properties of fucoidan isolated from Saccharina Japonica brown algae
Lymphoma
Antitumor activity of fucoidan against diffuse large B cell lymphoma in vitro and in vivo
Lung Cancer
Antitumor effect and molecular mechanism of fucoidan in NSCLC
Colon Cancer
Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling
Colon Cancer
Apoptosis inducing activity of Fucoidan in HCT-15 Colon Carcinoma Cells
Viral Infections
Are Bioactive Molecules from Seaweeds a Novel and Challenging Option for the Prevention of HPV Infection and Cervical Cancer Therapy?—A Review
Viral Infections (HPV)
Are Bioactive Molecules from Seaweeds a Novel and Challenging Option for the Prevention of HPV Infection?
Liver Disease
Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection
Immune Dysfunction
Biological Activities of Fucoidan and the Factors Mediating Its Therapeutic Effects: A Review of Recent Studies
Breast Cancer
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes
Breast Cancer
Brown Seaweed Fucoidan Inhibits Cancer Progression by Dual Regulation of mir-29c/ADAM12 and miR-17-5p/PTEN Axes in Human Breast Cancer Cells
Anti-inflammatory & Antioxidant
Characteristics and Antioxidant Activity of Fucoidan from Sargassum hystrix
Immune Dysfunction
Differential effects of Fucus vesiculosus fucoidan on fibroblast and macrophage cell lines inflammatory activation
Gastric Cancer
Effect of Fucoidan Dietary Supplement on the Chemotherapy Treatment of Patients with Unresectable Advanced Gastric Cancer
Skin Cancer
Effect of Fucoidan on B16 Murine Melanoma Cell Melanin Formation and Apoptosis
Immune Dysfunction
Effects of fucoidan supplementation on inflammatory and immune response after high-intensity exercise
Diabetes
Fucoidan – New Principle Prevention and Treatment for Diabetes
Kidney Disease
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome
Kidney Disease
Fucoidan Alleviates Renal Fibrosis in Diabetic Kidney Disease via Inhibition of NLRP3 Inflammasome-Mediated Podocyte Pyroptosis
Liver Disease
Fucoidan alleviates the hepatorenal syndrome through inhibition organic solute transporter α/β to reduce bile acids reabsorption
Diabetes
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage
Diabetes
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats
Immune Dysfunction
Fucoidan as a marine-origin prebiotic modulates the growth and antibacterial ability of Lactobacillus rhamnosus
IBD
Fucoidan attenuates chronic colitis and behavioral deficits by reshaping gut microbiota-brain axis balance
Lung Cancer
In Vitro Study
Fucoidan enhances the effect of chemotherapeutic drug against drug-resistant lung cancer cells
Breast Cancer
Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells
Breast Cancer
In Vitro Study
Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Cells
Leukemia
Fucoidan Extracted From Cladosiphon okamuranus Tokida Induces Apoptosis of Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines
Leukemia
Fucoidan Extracted From Cladosiphon okamuranus Tokida Induces Apoptosis of Human T-Cell Leukemia Virus Type 1-Infected T-Cell Lines and Primary Adult T-Cell Leukemia Cells
IBD
Fucoidan Extracts Ameliorate Acute Colitis
Immune Dysfunction
Fucoidan from Fucus vesiculosus can inhibit human norovirus replication by enhancing the host innate immune response
Immune Dysfunction
Fucoidan from Fucus vesiculosus Inhibits Inflammatory Response, Both In Vitro and In Vivo
Brain Tumors & Neuro
Fucoidan from Fucus vesiculosus prevents the loss of dopaminergic neurons by alleviating mitochondrial dysfunction through targeting ATP5F1a
Liver Disease
Fucoidan from Fucus vesiculosus suppresses hepatitis B virus replication by enhancing extracellular signal-regulated Kinase activation
Breast Cancer
In Vitro Study
Fucoidan from Laminaria japonica exerts antitumor effects on angiogenesis and micrometastasis in triple-negative breast cancer cells
Breast Cancer
Fucoidan from Lessonia trabeculata Induces Apoptosis through Caspase Dependent and Caspase-Independent Activation
Breast Cancer
Fucoidan from Lessonia trabeculata Induces Apoptosis through Caspase Dependent and Caspase-Independent Activation in 4T1 Breast Adenocarcinoma In Vitro
Pancreatic Cancer
Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53 – NFκB crosstalk
Pancreatic Cancer
In Vitro Study
Fucoidan from marine brown algae attenuates pancreatic cancer progression by regulating p53 – NFкB crosstalk
Lung Cancer
In Vitro Study
Fucoidan from seaweed Fucus vesiculosus inhibits migration and invasion of human lung cancer cell via PI3K-Akt-mTOR pathways
Pancreatic Cancer
Fucoidan from Turbinaria conoides: a multifaceted ‘deliverable’ to combat pancreatic cancer progression
Pancreatic Cancer
Fucoidan from Turbinaria conoides: a multifaceted deliverable to combat pancreatic cancer progression
Skin Cancer
Fucoidan Immobilized at the Surface of a Fibrous Mesh Presents Toxic Effects over Melanoma Cells
Prostate Cancer
Fucoidan Independently Enhances Activity in Human Immune Cells and Has a Cytostatic Effect on Prostate Cancer Cells in the Presence of Nivolumab
Prostate Cancer
In Vitro Study
Fucoidan Independently Enhances Activity in Human Immune Cells in the Presence of Nivolumab
Liver Cancer
In Vitro Study
Fucoidan Induces Apoptosis and Inhibits Proliferation of Hepatocellular Carcinoma via the p38 MAPK/ERK and PI3K/Akt Signal Pathways
Urinary Bladder Cancer
In Vitro Study
Fucoidan induces G1 arrest of the cell cycle in EJ human bladder cancer cells through down-regulation of pRB phosphorylation
Urinary Bladder Cancer
In Vitro Study
Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity
Urinary Bladder Cancer
Fucoidan Induces ROS-Dependent Apoptosis in 5637 Human Bladder Cancer Cells by Downregulating Telomerase Activity via Inactivation of the PI3K/Akt Signaling Pathway
Lung Cancer
In Vivo Study
Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation
Sarcoma
Fucoidan Inhibition of Osteosarcoma Cells is Species and Molecular Weight Dependent
Multiple Myeloma
Fucoidan inhibits angiogenesis induced by multiple myeloma cells
Immune Dysfunction
Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages
Immune Dysfunction
Fucoidan inhibits CCL22 production through NF-κB pathway in M2 macrophages: a potential therapeutic strategy for cancer
Liver Cancer
In Vitro Study
Fucoidan inhibits EGFR redistribution and potentiates sorafenib to overcome sorafenib-resistant hepatocellular carcinoma
Leukemia
Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways
Leukemia
Fucoidan inhibits proliferation of the SKM-1 acute myeloid leukaemia cell line via the activation of apoptotic pathways and production of reactive oxygen species
Prostate Cancer
Fucoidan Inhibits Prostate Cancer Growth Through Modulation of Different Cell Deaths
Urinary Bladder Cancer
In Vitro Study
Fucoidan Inhibits the Proliferation of Human Urinary Bladder Cancer T24 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis
IBD
Fucoidan modulates gut microbiota and immunity in Peyer’s patches against inflammatory bowel disease
Colon Cancer
In Vitro Study
Fucoidan present in brown algae induces apoptosis of human colon cancer cells
Autoimmune Diseases
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways
Autoimmune Diseases
Fucoidan prevent murine autoimmune diabetes via suppression TLR4-signaling pathways, regulation DC/Treg induced immune tolerance and improving gut microecology
Multiple Myeloma
Fucoidan prevents multiple myeloma cell escape from chemotherapy-induced drug cytotoxicity
Breast Cancer
Fucoidan Promotes Apoptosis and Inhibits EMT of Breast Cancer Cells
Parkinson's Disease
Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease
Diabetes
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress
Diabetes
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats
Lymphoma
Fucoidan Purified from Sargassum polycystum Induces Apoptosis through Mitochondria-Mediated Pathway in HL-60 and MCF-7 Cells
Colon Cancer
In Vitro Study
Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer
Alzheimer's Disease
Fucoidan serves a neuroprotective effect in an Alzheimer’s disease model
Diabetes
Fucoidan Structure and Its Impact on Glucose Metabolism: Implications for Diabetes and Cancer Therapy
Leukemia
Fucoidan Suppresses the Growth of Human Acute Promyelocytic Leukemia Cells In Vitro and In Vivo
Pancreatic Cancer
Fucoidan-Supplemented Diet Potentiates Immune Checkpoint Blockage by Enhancing Antitumor Immunity
Gallbladder Cancer
Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro
Renal Cancer
In Vitro Study
Fucoidan, a major component of brown seaweed, prohibits the growth of human cancer cell lines in vitro
Brain Tumors & Neuro
Fucoidan: a promising agent for brain injury and neurodegenerative disease intervention
Liver Disease
Fucoidan: Biological Activity in Liver Diseases
Pancreatic Cancer
In Vitro Study
Growth inhibition of pancreatic cancer by targeted delivery of gemcitabine via fucoidan-coated pH-sensitive liposomes
Immune Dysfunction
Immunopotentiating Activity of Fucoidans and Relevance to Cancer Immunotherapy
Anti-inflammatory & Antioxidant
In vitro Antioxidant Properties of Fucoidan Fractions From Sargassum tenerrimum
Sarcoma
In vivo immunomodulatory activity of fucoidan from brown alga Undaria pinnatifida in sarcoma 180-bearing mice
Leukemia
Induction of Apoptosis by Fucoidan in Human Leukemia U937 Cells through Activation of p38 MAPK and Modulation of Bcl-2 Family
Prostate Cancer
Investigation of Different Molecular Weight Fucoidan Fractions Derived from New Zealand Undaria pinnatifida in Combination with GroA Therapy in Prostate Cancer Cell Lines
Anti-inflammatory & Antioxidant
Isolation and antioxidant capacity of fucoidan from selected Malaysian seaweeds
Viral Infections (HPV)
LncRNA SELL/L-selectin promotes HPV-positive HNSCC progression and drives fucoidan-mediated therapeutic strategies
Liver Disease
Low molecular weight fucoidan attenuates liver injury via SIRT1/AMPK/PGC1α axis in db/db mice
Liver Disease
Low-molecular-weight fucoidan and high-stability fucoxanthin decrease serum alanine transaminase in patients with nonalcoholic fatty liver disease
Immune Dysfunction
Modulation of T Cell Responses by Fucoidan to Inhibit Osteogenesis
Viral Infections (HPV)
Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus?
Viral Infections
Natural Bioactives: Back to the Future in the Fight against Human Papillomavirus? A Narrative Review
Urinary Bladder Cancer
Natural Products as New Approaches for Treating Bladder Cancer
Urinary Bladder Cancer
Natural Products as New Approaches for Treating Bladder Cancer: From Traditional Medicine to Novel Drug Discovery
Pancreatic Cancer
Novel fucoidan based bioactive targeted nanoparticles from Undaria pinnatifida for treatment of pancreatic cancer
Viral Infections (HPV)
Potential Anti-HPV and Related Cancer Agents from Marine Resources: An Overview
Liver Disease
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway
Kidney Disease
Protective effects of fucoidan against kidney diseases (Int J Biol Macromol)
Kidney Disease
Protective effects of fucoidan against kidney diseases: Pharmacological insights and future perspectives
Immune Dysfunction
Recent insights of fucoidan probiotic and its effect on gut microbiota
Liver Cancer
In Vitro Study
Study of Oligo-Fucoidan in Advanced Hepatocellular Carcinoma (HCC)
Lung Cancer
In Vivo Study
Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF
Lung Cancer
Sulfated fucoidan FP08S2 inhibits lung cancer cell growth in vivo by disrupting angiogenesis via targeting VEGFR2/VEGF and blocking VEGFR2/Erk/VEGF signaling
Autoimmune Diseases
Sulfated Polysaccharide Fucoidan Ameliorates Experimental Autoimmune Myocarditis in Rats
Colon Cancer
In Vitro Study
Ten Years of Research on Fucoidan and Cancer: Focus on Its Antiangiogenic and Antimetastatic Effects
Liver Disease
The Ameliorative Effects of Fucoidan in Thioacetaide-Induced Liver Injury in Mice
Prostate Cancer
In Vitro Study
The anticancer effect of fucoidan in PC-3 prostate cancer cells
Alzheimer's Disease
The Application of Seaweed Polysaccharides and Their Derived Products with Potential for the Treatment of Alzheimer’s Disease
Sarcoma
The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines
Sarcoma
The Effect of Fucoidan, a Potential New, Natural, Anti-Neoplastic Agent on Uterine Sarcomas and Carcinosarcoma Cell Lines: ENITEC Collaborative Study
Breast Cancer
The Effect of Undaria pinnatifida Fucoidan on the Pharmacokinetics of Letrozole and Tamoxifen in Patients With Breast Cancer
Kidney Disease
The Emerging Evidence for a Protective Role of Fucoidan from Laminaria japonica in Chronic Kidney Disease-Triggered Cognitive Dysfunction
Kidney Disease
The Emerging Evidence for a Protective Role of Fucoidan from Laminaria japonica in CKD-Triggered Cognitive Dysfunction
Immune Dysfunction
The immunostimulatory effects of fucoidan on the cellular and humoral immune response in Wistar rats
Leukemia
The mechanism of fucoidan-induced apoptosis in leukemic cells: involvement of ERK1/2, JNK, glutathione, and nitric oxide
Skin Cancer
The natural compound fucoidan from New Zealand Undaria pinnatifida synergizes with the ERBB inhibitor lapatinib enhancing melanoma growth inhibition
Parkinson's Disease
Therapeutic Effects of Fucoidan in 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s disease
Parkinson's Disease
Therapeutic Effects of Fucoidan in 6-Hydroxydopamine-Lesioned Rat Model of Parkinson’s disease: Role of NADPH oxidase-1
Liver Disease
Therapeutic potential of fucoidan in the reduction of hepatic pathology in murine schistosomiasis japonica
Immune Dysfunction
Undaria pinnatifida Fucoidan-Rich Extract Recovers Immunity of Immunosuppressed Mice
Kidney Disease
Use of fucoidan to treat renal diseases: A review of 15 years of clinic studies
Renal Cancer
In Vitro Study
Use of fucoidan to treat renal diseases: A review of 15 years of clinic studies
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Research Summary
The study demonstrates that fucoidan, a carbohydrate from brown seaweed, significantly improves Type 2 Diabetes Mellitus (T2DM) in rats by repairing the intestinal barrier and reducing inflammation.
Key Metabolic & Liver Benefits:
- • Glucose Regulation: Reduced fasting blood glucose levels and lowered insulin resistance.
- • Liver Protection: Improved liver function through PI3K/AKT pathway activation.
- • Lipid Profiles: Balanced cholesterol and triglyceride levels.
Conclusion:
This research shows that even with low absorption, fucoidan provides strong systemic health benefits by targeting the gut-liver axis.